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Article

Transgenic Humanized AHR Mouse Reveals Differences between Human and Mouse AHR Ligand Selectivity

4 Aug 2009

Abstract excerpt

The Aryl-hydrocarbon receptor (AHR) is a ligand activated transcription factor involved in xenobiotic metabolism. Most of the toxic effects of halogenated and non-halogenated polycyclic aromatic hydrocarbons (HAHs and PAHs respectively) are mediated by the AHR. For the AHR, a number of intra and interspecies differences exist in terms of responsiveness to the prototypical AHR ligand...

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PMID: 20419055
DOI: 10.4255/mcpharmacol.09.15

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