Article
Novel role of hnRNP-A2/B1 in modulating aryl hydrocarbon receptor ligand sensitivity.
Archives of toxicology - 1 Nov 2015
Cho See-Wun, Suzuki Ken-ichi, Miura Yoshiaki, Miyazaki Tatsuhiko, Nose Masato, Iwata Hisato, Kim Eun-Young
Abstract excerpt
The aryl hydrocarbon receptor (AHR) is responsible for susceptibility to its ligand-dependent responses. However, the effect of non-AHR factors is less clear. To explore the non-AHR factors, we used two mouse strains with different AHR genetic variants, namely C3H/lpr and MRL/lpr strains with Ala and Val as the 375th amino acid residue, respectively. To assess the contribution of AHR alone, COS-7 cells...
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