Article
Unexpected diversity of aryl hydrocarbon receptors in non-mammalian vertebrates: insights from comparative genomics.
Journal of experimental zoology. Part A, Comparative experimental biology - 1 Sept 2006
Hahn Mark E, Karchner Sibel I, Evans Brad R, Franks Diana G, Merson Rebeka R, Lapseritis Joy M
Abstract excerpt
Ligand-activated receptors are well-known targets of environmental chemicals that disrupt endocrine signaling. Genomic approaches are providing new opportunities to understand the comparative biology and molecular evolution of these receptors. One example of this is the aryl hydrocarbon receptor (AHR), a basic-helix-loop-helix (bHLH)-Per-Arnt-Sim (PAS) transcription factor through which planar aromatic...
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