Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification of essential regions in the cytoplasmic tail of interleukin-1 receptor accessory protein critical for interleukin-1 signaling.

The Journal of biological chemistry - 10 May 2002

Radons Jurgen, Gabler Stefan, Wesche Holger, Korherr Christian, Hofmeister Robert, Falk Werner

Abstract excerpt

Interleukin (IL)-1 plays an important role in inflammation and regulation of immune responses. The activated IL-1 receptor complex, which consists of the IL-1 receptor type I and the IL-1 receptor accessory protein (IL-1RAcP), generates multiple cellular responses including NF-kappaB activation, IL-2 secretion, and IL-2 promoter activation. Reconstitution experiments in EL4D6/76 cells lacking IL-1RAcP expression...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytoplasm
Share to Interleukin-1

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Interleukin-2

Share to JNK Mitogen-Activated Protein Kinases

Share to Luciferases

Share to Mitogen-Activated Protein Kinases

Share to NF-kappa B

Share to Precipitin Tests

Source

Identifiers

PMID: 11880380
DOI: 10.1074/jbc.M201000200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of essential regions in the cytoplasmic tail of interleukin-1 receptor accessory protein critical for interleukin-1 signaling.PMID 11880380Read ↗

Interactive sites in the MyD88 Toll/interleukin (IL) 1 receptor domain responsible for coupling to the IL1beta signaling pathway.Semantic proximity Read ↗

Identification of critical regions within the TIR domain of IL-1 receptor type I.Semantic proximity Read ↗

Identification of Two Major Sites in the Type I Interleukin-1 Receptor Cytoplasmic Region Responsible for Coupling to Pro-inflammatory Signaling PathwaysSemantic proximity Read ↗

Antibodies targeting the shared cytokine receptor IL-1 receptor accessory protein invoke distinct mechanisms to block all cytokine signalingSemantic proximity Read ↗

A molecular mechanism for Toll-IL-1 receptor domain-containing adaptor molecule-1-mediated IRF-3 activation.Semantic proximity Read ↗

Structure and function of the intracellular portion of the mouse interleukin 1 receptor (type I). Determining the essential region for transducing signals to activate the interleukin 8 gene.Semantic proximity Read ↗

The Interleukin-1 Receptor/Toll-Like Receptor Superfamily: Signal Transduction During Inflammation and Host DefenseSemantic proximity Read ↗

The Interleukin-1 Receptor/Toll-Like Receptor Superfamily: Signal Transduction During Inflammation and Host DefenseSemantic proximity Read ↗

Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor.Semantic proximity Read ↗

MyD88 adapter-like (Mal)/TIRAP interaction with TRAF6 is critical for TLR2- and TLR4-mediated NF-kappaB proinflammatory responses.Semantic proximity Read ↗

Molecular interactions in interleukin and toll-like receptor signaling pathways.Semantic proximity Read ↗

Common interaction surfaces of the toll-like receptor 4 cytoplasmic domain stimulate multiple nuclear targets.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.