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Article

Identification of critical regions within the TIR domain of IL-1 receptor type I.

The international journal of biochemistry & cell biology - 1 Nov 2015

Radons Jürgen, Falk Werner, Dove Stefan

Abstract excerpt

Interleukin-1 receptor type I (IL-1RI) belongs to a superfamily of proteins characterized by an intracellular Toll/IL-1 receptor (TIR) domain. This domain harbors three conserved regions called boxes 1-3 that play crucial roles in mediating IL-1 responses. Boxes 1 and 2 are considered to be involved in binding of adapter molecules. Amino acids possibly crucial for IL-1RI signaling were predicted via homology...

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Identifiers

PMID: 26279140
DOI: 10.1016/j.biocel.2015.08.009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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