Article
Genetic mutations and aminoglycoside-induced ototoxicity in neonates.
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery - 1 May 2010
Johnson Romaine F, Cohen Aliza P, Guo Yingshi, Schibler Kurt, Greinwald John H
Abstract excerpt
OBJECTIVE: Mutations in the 12S rRNA gene have been associated with aminoglycoside-induced ototoxicity. Our objective was to study the relationship of these mutations in neonates, duration of aminoglycoside exposure, and other known risk factors to the presence of hearing loss. STUDY DESIGN: Prospective case-cohort study. SETTING: Three neonatal intensive care units (NICUs) in Cincinnati, OH. SUBJECTS AND...
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