Article
Aminoglycoside ototoxicity in Nicaraguan children: patient risk factors and mitochondrial DNA results.
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery - 1 Jan 2009
Saunders James E, Greinwald John H, Vaz Sharon, Guo Yinshi
Abstract excerpt
OBJECTIVE: Aminoglycoside ototoxicity remains a major problem in developing countries and accounts for 3 percent to 30 percent of hearing loss. This high prevalence rate may be related to genetic susceptibility from mitochondrial mutations in the 12S rRNA gene, comorbidity factors, or unregulated use of the medication. This study investigates the risk factors and prevalence of mtDNA mutations in serum from rural...
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