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Article

Mutational analysis of the mitochondrial 12S rRNA gene in Chinese pediatric subjects with aminoglycoside-induced and non-syndromic hearing loss.

Human genetics - 1 Jun 2005

Li Zhiyuan, Li Ronghua, Chen Jianfu, Liao Zhisu, Zhu Yi, Qian Yaping, Xiong Sudao, Heman-Ackah Selena, Wu Jianbo, Choo Daniel I, Guan Min-Xin

Abstract excerpt

Mutations in mitochondrial DNA (mtDNA) have been found to be associated with sensorineural hearing loss. We report here a systematic mutational screening of the mitochondrial 12S rRNA gene in 128 Chinese pediatric subjects with sporadic aminoglycoside-induced and non-syndromic hearing loss. We show that aminoglycoside ototoxicity accounts for 48% of cases of hearing loss in this Chinese pediatric population. Of...

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Identifiers

PMID: 15841390
DOI: 10.1007/s00439-005-1276-1
PMCID: PMC1484504

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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