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Article

Mitochondrial gene mutation is a significant predisposing factor in aminoglycoside ototoxicity.

American journal of otolaryngology - 1 Jan 2000

Fischel-Ghodsian N, Prezant T R, Chaltraw W E, Wendt K A, Nelson R A, Arnos K S, Falk R E

Abstract excerpt

PURPOSE: Aminoglycoside-induced deafness caused by mutations in the mitochondrial 12S ribosomal RNA gene has been described in a number of Asian patients. The purpose of the current study is to analyze ethnically diverse patients in the United States with hearing loss after aminoglycoside exposure for presence or absence of these mitochondrial DNA mutations, and establish the frequency and clinical presentation...

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Identifiers

PMID: 9164619
DOI: 10.1016/s0196-0709(97)90078-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Mitochondrial gene mutation is a significant predisposing factor in aminoglycoside ototoxicity.PMID 9164619Read ↗

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