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Article

Audiologic testing and molecular analysis of 12S rRNA in patients receiving aminoglycosides.

The Laryngoscope - 1 Apr 2005

Gürtler Nicolas, Schmuziger Nicolas, Kim Yuil, Mhatre Anand N, Jungi Manuel, Lalwani Anil K

Abstract excerpt

BACKGROUND: Pathogenic mutations in the mitochondrial genome are associated with a wide variety of maternally inherited human diseases including sensorineural hearing loss (HL). A specific mutation, m.1555A>G in the mitochondrial 12S rRNA gene, is associated with predisposition to aminoglycoside ototoxicity and HL. Mutation screening in this gene has been recommended before use of aminoglycosides as a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15805873
DOI: 10.1097/01.mlg.0000161355.28073.f5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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