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Article

Lower frequency of the low activity adenosine deaminase allelic variant (ADA1*2) in schizophrenic patients.

Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) - 1 Sept 2010

Dutra Gustavo Pimentel, Ottoni Gustavo L, Lara Diogo R, Bogo Maurício Reis

Abstract excerpt

OBJECTIVE: Adenosine may play a role in the pathophysiology of schizophrenia, since it modulates the release of several neurotransmitters such as glutamate, dopamine, serotonin and acetylcholine, decreases neuronal activity by pos-synaptic hyperpolarization and inhibits dopaminergic activity. Adenosine deaminase participates in purine metabolism by converting adenosine into inosine. The most frequent functional...

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Source

Identifiers

PMID: 20414589
DOI: 10.1590/s1516-44462010005000003

Genes

ADA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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