Functional ADA polymorphism increases sleep depth and reduces vigilant attention in humans.

doi:10.1093/cercor/bhr173

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Article

Functional ADA polymorphism increases sleep depth and reduces vigilant attention in humans.

Cerebral cortex (New York, N.Y. : 1991) - 1 Apr 2012

Bachmann Valérie, Klaus Federica, Bodenmann Sereina, Schäfer Nikolaus, Brugger Peter, Huber Susanne, Berger Wolfgang, Landolt Hans-Peter

Abstract excerpt

Homeostatically regulated slow-wave oscillations in non-rapid eye movement (REM) sleep may reflect synaptic changes across the sleep-wake continuum and the restorative function of sleep. The nonsynonymous c.22G>A polymorphism (rs73598374) of adenosine deaminase (ADA) reduces the conversion of adenosine to inosine and predicts baseline differences in sleep slow-wave oscillations. We hypothesized that this...

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PMID: 21734253
DOI: 10.1093/cercor/bhr173

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