Article
The ADA*2 allele of the adenosine deaminase gene (20q13.11) and recurrent spontaneous abortions: an age-dependent association.
Clinics (Sao Paulo, Brazil) - 1 Jan 2011
Nunes Daniela Prudente Teixeira, Spegiorin Lígia Cosentino Junqueira Franco, Mattos Cinara Cássia Brandão de, Oliani Antonio Helio, Vaz-Oliani Denise Cristina Mós, Mattos Luiz Carlos de
Abstract excerpt
OBJECTIVE: Adenosine deaminase acts on adenosine and deoxyadenosine metabolism and modulates the immune response. The adenosine deaminase G22A polymorphism (20q.11.33) influences the level of adenosine deaminase enzyme expression, which seems to play a key role in maintaining pregnancy. The adenosine deaminase 2 phenotype has been associated with a protective effect against recurrent spontaneous abortions in...
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