Article
Baicalein blocks α-synuclein secretion from SN4741 cells and facilitates α-synuclein polymerization to big complex.
Neuroscience letters - 10 Aug 2017
Li Xingjian, Zhang Guofeng, Nie Qi, Wu Ting, Jiao Luyan, Zheng Meige, Wan Xiaomei, Li Yonglin, Wu Song, Jiang Bin, Xiang Xianhong, Duan Jinhai, Lin Xian
Abstract excerpt
The secretion of α-synuclein (α-syn) acts as an essential driver in the propagation of synucleinopathies in brain. The clearance of extracellular α-syn or blockade of the cell-to-cell transmission of α-syn is a promising approach to prohibiting synucleinopathies propagation. Baicalein (BAI), a flavonoid from Chinese herb, has been reported to bind covalently to α-syn to inhibit α-syn fibrillation and degrade its...
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