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Article

Transforming Growth Factor-.BETA. Upregulates the Expression of Integrin and Related Proteins in MRC-5 Human Myofibroblasts

1 Jan 2010

Abstract excerpt

Myofibroblasts are defined as fibroblasts that express certain features of smooth muscle differentiation. Activation of myofibroblasts plays a central role in fibrosis. Transforming growth factor-beta (TGF-beta) is a potent activator of myofibroblasts; namely, TGF-beta causes changes in myofibroblast phenotypes including morphological alterations and the expression of alpha-smooth muscle actin (alpha-SMA), a...

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PMID: 20410683
DOI: 10.1620/tjem.220.319

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