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Article

The fibroblast integrin alpha11beta1 is induced in a mechanosensitive manner involving activin A and regulates myofibroblast differentiation.

The Journal of biological chemistry - 2 Apr 2010

Carracedo Sergio, Lu Ning, Popova Svetlana N, Jonsson Roland, Eckes Beate, Gullberg Donald

Abstract excerpt

Fibrotic tissue is characterized by an overabundance of myofibroblasts. Thus, understanding the factors that induce myofibroblast differentiation is paramount to preventing fibrotic healing. Previous studies have shown that mechanical stress derived from the integrin-mediated interaction between extracellular matrix and the cytoskeleton promotes myofibroblast differentiation. Integrin alpha11beta1 is a collagen...

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Activins
Cell Culture Techniques
Collagen
Cornea
Cytoskeleton

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Transforming Growth Factor beta1

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PMID: 20129924
DOI: 10.1074/jbc.M109.078766
PMCID: PMC2856250

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