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Article

αv integrins play an important role in myofibroblast differentiation

19 Jul 2004

Abstract excerpt

Transforming growth factor-beta1 is a potent mediator of the differentiation of fibroblasts into myofibroblasts, which is characterized by the appearance of the cytoskeletal protein alpha-smooth muscle actin. The aim of this study was to investigate the role of integrin extracellular matrix receptors in transforming growth factor-beta1-induced myofibroblast differentiation. We show that blockade of the alphav...

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PMID: 15260812
DOI: 10.1111/j.1067-1927.2004.12402.x

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