Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

FAK is required for TGFbeta-induced JNK phosphorylation in fibroblasts: implications for acquisition of a matrix-remodeling phenotype.

Molecular biology of the cell - 1 Jun 2007

Liu Shangxi, Xu Shi-wen, Kennedy Laura, Pala Daphne, Chen Yunliang, Eastwood Mark, Carter David E, Black Carol M, Abraham David J, Leask Andrew

Abstract excerpt

Transforming growth factor beta (TGFbeta) plays a critical role in connective tissue remodeling by fibroblasts during development, tissue repair, and fibrosis. We investigated the molecular pathways in the transmission of TGFbeta signals that lead to features of connective tissue remodeling, name...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Enzyme Activation
Share to Extracellular Matrix
Share to Fibroblasts

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Focal Adhesion Kinase 2

Share to JNK Mitogen-Activated Protein Kinases

Share to MAP Kinase Kinase Kinase 1

Share to Stress Fibers

Share to Transforming Growth Factor beta

Source

Open in PubMed Open full text

Identifiers

PMID: 17409352
DOI: 10.1091/mbc.e06-12-1121
PMCID: PMC1877111

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17409352-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

FAK is required for TGFbeta-induced JNK phosphorylation in fibroblasts: implications for acquisition of a matrix-remodeling phenotype.PMID 17409352Read ↗

p38 mitogen-activated protein kinase is required for TGFbeta-mediated fibroblastic transdifferentiation and cell migration.Semantic proximity Read ↗

MEKK1 transduces activin signals in keratinocytes to induce actin stress fiber formation and migration.Semantic proximity Read ↗

Focal adhesion kinase signaling determines the fate of lung epithelial cells in response to TGF-β.Semantic proximity Read ↗

Combinatorial activation of FAK and AKT by transforming growth factor-beta1 confers an anoikis-resistant phenotype to myofibroblasts.Semantic proximity Read ↗

Involvement of the FAK Network in Pathologies Related to Altered MechanotransductionSemantic proximity Read ↗

Signaling in Fibrosis: TGF-β, WNT, and YAP/TAZ ConvergeSemantic proximity Read ↗

PAK proteins and YAP-1 signalling downstream of integrin beta-1 in myofibroblasts promote liver fibrosis.Semantic proximity Read ↗

Snail1 controls epithelial-mesenchymal lineage commitment in focal adhesion kinase-null embryonic cells.Semantic proximity Read ↗

Smooth muscle alpha-actin expression and myofibroblast differentiation by TGFbeta are dependent upon MK2.Semantic proximity Read ↗

Combinatorial signaling pathways determine fibroblast proliferation and myofibroblast differentiationSemantic proximity Read ↗

Actin Cytoskeleton and Regulation of TGFβ Signaling: Exploring Their LinksSemantic proximity Read ↗

Tensin can induce JNK and p38 activation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.