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Article

A genome-wide linkage scan reveals CD53 as an important regulator of innate TNF-alpha levels.

European journal of human genetics : EJHG - 1 Aug 2010

Bos Steffan D, Lakenberg Nico, van der Breggen Ruud, Houwing-Duistermaat Jeanine J, Kloppenburg Margreet, de Craen Anton J M, Beekman Marian, Meulenbelt Ingrid, Slagboom P Eline

Abstract excerpt

Cytokines are major immune system regulators. Previously, innate cytokine profiles determined by lipopolysaccharide stimulation were shown to be highly heritable. To identify regulating genes in innate immunity, we analyzed data from a genome-wide linkage scan using microsatellites in osteoarthritis (OA) patients (The GARP study) and their innate cytokine data on interleukin (IL)-1beta, IL-1Ra, IL-10 and tumor...

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Share to Antigens, Differentiation, T-Lymphocyte
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20407468
DOI: 10.1038/ejhg.2010.52
PMCID: PMC2987381

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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