Contribution for new genetic markers of rheumatoid arthritis activity and severity: sequencing of the tumor necrosis factor-alpha gene promoter.

doi:10.1186/ar2173

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Article

Contribution for new genetic markers of rheumatoid arthritis activity and severity: sequencing of the tumor necrosis factor-alpha gene promoter.

Arthritis research & therapy - 1 Jan 2007

Fonseca João Eurico, Cavaleiro João, Teles José, Sousa Elsa, Andreozzi Valeska L, Antunes Marília, Amaral-Turkman Maria A, Canhão Helena, Mourão Ana F, Lopes Joana, Caetano-Lopes Joana, Weinmann Pamela, Sobral Marta, Nero Patrícia, Saavedra Maria J, Malcata Armando, Cruz Margarida, Melo Rui, Braña Araceli, Miranda Luis, Patto José V, Barcelos Anabela, da Silva José Canas, Santos Luís M, Figueiredo Guilherme, Rodrigues Mário, Jesus Herberto, Quintal Alberto, Carvalho Teresa, da Silva José A Pereira, Branco Jaime, Queiroz Mário Viana

Abstract excerpt

The objective of this study was to assess whether clinical measures of rheumatoid arthritis activity and severity were influenced by tumor necrosis factor-alpha (TNF-alpha) promoter genotype/haplotype markers. Each patient's disease activity was assessed by the disease activity score using 28 joint counts (DAS28) and functional capacity by the Health Assessment Questionnaire (HAQ) score. Systemic manifestations,...

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PMID: 17408492
DOI: 10.1186/ar2173
PMCID: PMC1906815

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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