Article
Genomic scan of 254 hereditary prostate cancer families.
The Prostate - 1 Dec 2003
Janer Marta, Friedrichsen Danielle M, Stanford Janet L, Badzioch Michael D, Kolb Suzanne, Deutsch Kerry, Peters Mette A, Goode Ellen L, Welti Russ, DeFrance Hawkins B, Iwasaki Lori, Li Sarah, Hood Leroy, Ostrander Elaine A, Jarvik Gail P
Abstract excerpt
Hereditary prostate cancer (HPC) is a genetically heterogeneous disease, complicating efforts to map and clone susceptibility loci. We have used stratification of a large dataset of 254 HPC families in an effort to improve power to detect HPC loci and to understand what types of family features may improve locus identification. The strongest result is that of a dominant locus at 6p22.3 (heterogeneity LOD (HLOD) =...
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