Article
Genome-wide scan of Swedish families with hereditary prostate cancer: suggestive evidence of linkage at 5q11.2 and 19p13.3.
The Prostate - 1 Dec 2003
Wiklund Fredrik, Gillanders Elizabeth M, Albertus Julie A, Bergh Anders, Damber Jan-Erik, Emanuelsson Monica, Freas-Lutz Diana L, Gildea Derek E, Göransson Ingela, Jones MaryPat S, Jonsson Björn-Anders, Lindmark Fredrik, Markey Carol J, Riedesel Erica L, Stenman Elisabeth, Trent Jeffry M, Grönberg Henrik
Abstract excerpt
BACKGROUND: Prostate cancer (CaP) is a common disorder with multiple genetic and environmental factors contributing to the disease. CaP susceptibility loci can be identified through genome-wide scans of high-risk families. METHODS: Allele sharing at 405 markers, distributed across the genome, among 50 families with hereditary prostate cancer, ascertained throughout Sweden, was evaluated through linkage analyses....
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