Article
Genome-wide scan for linkage in finnish hereditary prostate cancer (HPC) families identifies novel susceptibility loci at 11q14 and 3p25-26.
The Prostate - 1 Dec 2003
Schleutker Johanna, Baffoe-Bonnie Agnes B, Gillanders Elizabeth, Kainu Tommi, Jones Mary-Pat, Freas-Lutz Diana, Markey Carol, Gildea Derek, Riedesel Erica, Albertus Julie, Gibbs Kenneth D, Matikainen Mika, Koivisto Pasi A, Tammela Teuvo, Bailey-Wilson Joan E, Trent Jeffrey M, Kallioniemi Olli-P
Abstract excerpt
BACKGROUND: In order to identify predisposition loci to hereditary prostate cancer (HPC), we performed a genome-wide linkage analysis using samples from a genetically homogeneous population, with 13 Finnish multiplex prostate cancer families. METHODS: Altogether 87 DNA samples were genotyped from 13 families. Logarithm-of-odds (LOD) scores were calculated for all autosomes using FASTLINK and GENEHUNTER...
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