Article
The locus controlling pineal serotonin N-acetyltransferase activity (Nat-2) is located on mouse chromosome 11.
Brain research. Molecular brain research - 1 Feb 1994
Goto M, Oshima I, Hasegawa M, Ebihara S
Abstract excerpt
Melatonin is synthesized from serotonin by the enzymes serotonin N-acetyltransferase (SNAT) and hydroxyindole-O-methyl-transferase (HIOMT). We have previously reported that C57BL/6 mice do not have SNAT activity because of a mutation in an autosomal gene which is responsible for the absence of no...
Topics
- Acetylserotonin O-Methyltransferase
- Alleles
- Animals
- Arylamine N-Acetyltransferase
- Chromosome Mapping
- Female
- Gene Expression Regulation, Enzymologic
- Genetic Linkage
- Male
- Mice
- Mice, Inbred C3H
- Mice, Inbred C57BL