Article
Arylalkylamine N-acetyltransferase (AANAT) genotype as a personal trait in melatonin synthesis.
Journal of toxicology and environmental health. Part A - 1 Jan 2008
Blomeke Brunhilde, Golka Klaus, Griefahn Barbara, Roemer Hermann C
Abstract excerpt
The melatonin rhythm is arguably the best marker for the phase of the endogenous "biological clock." Arylalkylamine N-acetyltransferase (AANAT) is known to catalyze the acetylation of serotonin, a rate-limiting process in melatonin synthesis. Different single-nucleotide polymorphisms (SNPs) in the AANAT gene were identified recently in the Japanese population, and one of the genes was significantly associated...
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