Article
Significant association of the arylalkylamine N-acetyltransferase ( AA-NAT) gene with delayed sleep phase syndrome.
Neurogenetics - 1 Apr 2003
Hohjoh Hirohiko, Takasu Miwa, Shishikura Kaori, Takahashi Yasurou, Honda Yutaka, Tokunaga Katsushi
Abstract excerpt
Arylalkylamine N-acetyltransferase (AA-NAT) is a rate-limiting enzyme in melatonin hormone synthesis and participates in daily oscillations of the melatonin level. We studied the association between the AA-NAT gene and delayed sleep phase syndrome (DSPS). Results indicate that there is a significant difference in allele positivity at the single nucleotide polymorphism involved in an amino acid substitution from...
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