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Article

Prions are secreted into the oral cavity in sheep with preclinical scrapie.

The Journal of infectious diseases - 1 Jun 2010

Maddison Ben C, Rees Helen C, Baker Claire A, Taema Maged, Bellworthy Susan J, Thorne Leigh, Terry Linda A, Gough Kevin C

Abstract excerpt

A major concern in prion disease transmission is the spread of the disease agent by means of secretions and excretions. We analyzed buccal swab samples obtained from preclinical scrapie-infected sheep by concentrating the collected prions on silicon dioxide, followed by amplification by serial protein misfolding cyclic amplification. Data clearly demonstrate that prions are present in buccal swab samples from...

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Source

Identifiers

PMID: 20402590
DOI: 10.1086/652457

Genes

PRNP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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