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Article

Detection of PrP(Sc) in rectal biopsy and necropsy samples from sheep with experimental scrapie.

Journal of comparative pathology - 1 Jan 2000

Espenes A, Press C McL, Landsverk T, Tranulis M A, Aleksandersen M, Gunnes G, Benestad S L, Fuglestveit R, Ulvund M J

Abstract excerpt

Scrapie diagnosis is based on the demonstration of disease-associated prion protein (PrP(Sc)) in brain or, in the live animal, in readily accessible peripheral lymphoid tissue. Lymphatic tissues present at the rectoanal line were readily obtained from sheep without the need for anaesthesia. The presence of PrP(Sc) in such tissue was investigated in sheep infected orally with scrapie-infected brain material. The...

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Identifiers

PMID: 16466737
DOI: 10.1016/j.jcpa.2005.08.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Detection of PrP(Sc) in rectal biopsy and necropsy samples from sheep with experimental scrapie.PMID 16466737Read ↗

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An assessment of the efficiency of PrPsc detection in rectal mucosa and third-eyelid biopsies from animals infected with scrapie.Semantic proximity Read ↗

PrP(Sc) deposition in nervous tissues without lymphoid tissue involvement is frequently found in ARQ/ARQ Sarda breed sheep preclinically affected with natural scrapie.Semantic proximity Read ↗

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