Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Lifetime Cancer Risks in Individuals with Germline<i>PTEN</i>Mutations

15 Jan 2012

Abstract excerpt

PURPOSE: Age-adjusted cancer incidence and age-related penetrance studies have helped guide cancer risk assessment and management. PTEN hamartoma tumor syndrome (PHTS) is a term encompassing subsets of several clinical syndromes with germline mutations in the PTEN tumor suppressor gene. We conducted the first prospective study to clarify corresponding cancer risks to shed biologic insights on human germline PTEN...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biological Research and Disease Studies
Share to Male Breast Health Studies
Share to PI3K/AKT/mTOR signaling in cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22252256
DOI: 10.1158/1078-0432.ccr-11-2283

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Lifetime Cancer Risks in Individuals with Germline<i>PTEN</i>MutationsPMID 22252256Read ↗

High cumulative risks of cancer in patients with <i>PTEN</i> hamartoma tumour syndromeSemantic proximity Read ↗

A review on age‐related cancer risks in PTEN hamartoma tumor syndromeSemantic proximity Read ↗

Cancer risks by sex and variant type in PTEN hamartoma tumor syndromeSemantic proximity Read ↗

PTEN hamartoma tumor syndrome: clinical risk assessment and management protocol.Semantic proximity Read ↗

PTEN hamartoma tumour syndrome: what happens when there is no PTEN germline mutation?Semantic proximity Read ↗

Extended spectrum of cancers in PTEN hamartoma tumor syndromeSemantic proximity Read ↗

Cancer Risk Associated With PTEN Pathogenic Variants Identified Using Multigene Hereditary Cancer Panel Testing.Semantic proximity Read ↗

PTEN hamartoma tumor syndromes.Semantic proximity Read ↗

The Clinical Spectrum of PTEN MutationsSemantic proximity Read ↗

Breast cancer risk and clinical implications for germline PTEN mutation carriers.Semantic proximity Read ↗

WWP1 Gain-of-Function Inactivation of PTEN in Cancer Predisposition.Semantic proximity Read ↗

PTEN hamartoma tumor syndrome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.