Article
The miRNA machinery targets Mei-P26 and regulates Myc protein levels in the Drosophila wing.
The EMBO journal - 19 May 2010
Herranz Héctor, Hong Xin, Pérez Lidia, Ferreira Ana, Olivieri Daniel, Cohen Stephen M, Milán Marco
Abstract excerpt
MicroRNAs (miRNAs) have been implicated in cell-cycle regulation and in some cases shown to have a role in tissue growth control. Depletion of miRNAs was found to have an effect on tissue growth rates in the wing primordium of Drosophila, a highly proliferative epithelium. Dicer-1 (Dcr-1) is a double-stranded RNAseIII essential for miRNA biogenesis. Adult cells lacking dcr-1, or with reduced dcr-1 activity, were...
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