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Article

Generation of a family-specific phage library of llama single chain antibody fragments that neutralize HIV-1.

The Journal of biological chemistry - 18 Jun 2010

Koh Willie W L, Steffensen Soren, Gonzalez-Pajuelo Maria, Hoorelbeke Bart, Gorlani Andrea, Szynol Agnieszka, Forsman Anna, Aasa-Chapman Marlén M I, de Haard Hans, Verrips Theo, Weiss Robin A

Abstract excerpt

Recently, we described llama antibody fragments (VHH) that can neutralize human immunodeficiency virus, type 1 (HIV-1). These VHH were obtained after selective elution of phages carrying an immune library raised against gp120 of HIV-1 subtype B/C CN54 with soluble CD4. We describe here a new, family-specific approach to obtain the largest possible diversity of related VHH that compete with soluble CD4 for binding...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20400507
DOI: 10.1074/jbc.M110.116699
PMCID: PMC2885190

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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