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Cross-clade HIV-1 neutralization by an antibody fragment from a lupus phage display library

1 Jan 2004

Abstract excerpt

A single-chain fragment containing antibody V domains (scFv) isolated from a lupus antibody library displayed the ability to bind gp120 and the conserved gp120 determinant composed of residues 421–436. The scFv neutralized R5 and X4-dependent HIV-1 strains from clades B, C and D. The lupus repertoire may be useful as a source of neutralizing antibodies to HIV. The mutability of the immunodominant epitopes of HIV...

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PMID: 15075554
DOI: 10.1097/00002030-200401230-00026

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