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Article

Selection of nanobodies with broad neutralizing potential against primary HIV-1 strains using soluble subtype C gp140 envelope trimers.

Scientific reports - 21 Aug 2017

Koch Kathrin, Kalusche Sarah, Torres Jonathan L, Stanfield Robyn L, Danquah Welbeck, Khazanehdari Kamal, von Briesen Hagen, Geertsma Eric R, Wilson Ian A, Wernery Ulrich, Koch-Nolte Friedrich, Ward Andrew B, Dietrich Ursula

Abstract excerpt

Broadly neutralizing antibodies (bnAbs) against HIV-1 protect from infection and reduce viral load upon therapeutic applications. However no vaccine was able so far to induce bnAbs demanding their expensive biotechnological production. For clinical applications, nanobodies (VHH) derived from heavy chain only antibodies from Camelidae, may be better suited due to their small size, high solubility/stability and...

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Share to Antibodies, Neutralizing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to env Gene Products, Human Immunodeficiency Virus

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Source

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Identifiers

PMID: 28827559
DOI: 10.1038/s41598-017-08273-7
PMCID: PMC5566552

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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