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Article

Molecular evolution of broadly neutralizing Llama antibodies to the CD4-binding site of HIV-1.

PLoS pathogens - 1 Dec 2014

McCoy Laura E, Rutten Lucy, Frampton Dan, Anderson Ian, Granger Luke, Bashford-Rogers Rachael, Dekkers Gillian, Strokappe Nika M, Seaman Michael S, Koh Willie, Grippo Vanina, Kliche Alexander, Verrips Theo, Kellam Paul, Fassati Ariberto, Weiss Robin A

Abstract excerpt

To date, no immunization of humans or animals has elicited broadly neutralizing sera able to prevent HIV-1 transmission; however, elicitation of broad and potent heavy chain only antibodies (HCAb) has previously been reported in llamas. In this study, the anti-HIV immune responses in immunized ll...

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Share to AIDS Vaccines
Share to Antibodies, Neutralizing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Antigens, Viral

Share to Binding Sites, Antibody

Share to Camelids, New World

Share to CD4 Antigens

Share to HIV Infections

Share to Immunoglobulin Variable Region

Source

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Identifiers

PMID: 25522326
DOI: 10.1371/journal.ppat.1004552
PMCID: PMC4270772

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25522326-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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