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Middle-aged human apoE4 targeted-replacement mice show retention deficits on a wide range of spatial memory tasks.

Behavioural brain research - 21 Nov 2008

Bour Alexandra, Grootendorst Jeannette, Vogel Elise, Kelche Christian, Dodart Jean-Cosme, Bales Kelly, Moreau Pierre-Henri, Sullivan Patrick M, Mathis Chantal

Abstract excerpt

Apolipoprotein (apo) E4, one of three human apoE (h-apoE) isoforms, has been identified as a major genetic risk factor for Alzheimer's disease and for cognitive deficits associated with aging. However, the biological mechanisms involving apoE in learning and memory processes are unclear. A potential isoform-dependent role of apoE in cognitive processes was studied in human apoE targeted-replacement (TR) mice....

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Source

Identifiers

PMID: 18572260
DOI: 10.1016/j.bbr.2008.05.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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