Sequence variations in the 5' flanking and IVS-II regions of the G gamma- and A gamma-globin genes of beta S chromosomes with five different haplotypes.

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Article

Sequence variations in the 5' flanking and IVS-II regions of the G gamma- and A gamma-globin genes of beta S chromosomes with five different haplotypes.

Blood - 1 Jun 1991

Lanclos K D, Oner C, Dimovski A J, Gu Y C, Huisman T H

Abstract excerpt

We have amplified and sequenced the 5' flanking and the second intervening sequence (IVS-II) regions of both the G gamma- and A gamma-globin genes of the beta S chromosomes from sickle cell anemia (SS) patients with homozygosities for five different haplotypes. The sequencing data, compared with previously published sequences for the normal chromosomes A and B, show many similarities to chromosome B for...

Topics

Anemia, Sickle Cell
Base Sequence
Chromosome Deletion
Chromosomes, Human, 1-3
Chromosomes, Human, 4-5
DNA
Gene Amplification
Genetic Variation
Globins
Haplotypes
Homozygote

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Introns

Molecular Sequence Data

Mutation

Nucleic Acid Hybridization

Oligonucleotide Probes

Reference Values

Source

Open in PubMed

Identifiers

PMID: 2039830

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2039830-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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