Article
Molecular genetic studies in black families with sickle cell anemia and unusually high levels of fetal hemoglobin.
Hemoglobin - 1 Jan 1992
Seltzer W K, Abshire T C, Lane P A, Roloff J S, Githens J H
Abstract excerpt
Clinical, hematologic, and molecular genetic studies are reported for five families with SS patients having unusually high fetal hemoglobin (Hb F) levels (mean 28.3%, range 19-42%). Some of the individuals were symptom-free and one was not anemic. However, some were symptomatic despite a very high Hb F. Neither the Hb F level nor the F cell distribution entirely explained the variation in clinical severity....
Topics
- Adult
- Aged
- Anemia, Sickle Cell
- Black People
- Child
- Child, Preschool
- DNA
- Female
- Fetal Hemoglobin
- Gene Deletion
- Genotype
- Globins