Two mutations in the locus control region hypersensitivity site-2 (5' HS-2) of haplotype 19 beta s chromosomes alter binding of trans-acting factors.

doi:10.1002/(SICI)1096-8652(199601)51:1<12::AID-AJH3>3.0.CO;2-A

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Article

Two mutations in the locus control region hypersensitivity site-2 (5' HS-2) of haplotype 19 beta s chromosomes alter binding of trans-acting factors.

American journal of hematology - 1 Jan 1996

Morgan J C, Scott D F, Lanclos K D

Abstract excerpt

There are five major haplotypes associated with sickle cell anemia (SS). Individuals homozygous for haplotypes 3 (Senegal) and 31 (Saudi Arabian) have high fetal hemoglobin (HbF) levels (15 to 30% of total hemoglobin) whereas individuals homozygous for haplotypes 17 (Cameroon), 19 (Benin), and 20...

Topics

Base Sequence
Cell Line
Chromosomes, Human, Pair 11
DNA
DNA-Binding Proteins
Enhancer Elements, Genetic
Fetal Hemoglobin
Gene Expression Regulation
Genes, Switch
Globins
Haplotypes
HeLa Cells
Hemoglobin, Sickle
Humans
Lung
Molecular Sequence Data
Mutation
Protein Binding

Source

Open in PubMed

Identifiers

PMID: 8571932
DOI: 10.1002/(SICI)1096-8652(199601)51:1<12::AID-AJH3>3.0.CO;2-A

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8571932-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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