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Article

Two mutations in the locus control region hypersensitivity site-2 (5' HS-2) of haplotype 19 beta s chromosomes alter binding of trans-acting factors.

American journal of hematology - 1 Jan 1996

Morgan J C, Scott D F, Lanclos K D

Abstract excerpt

There are five major haplotypes associated with sickle cell anemia (SS). Individuals homozygous for haplotypes 3 (Senegal) and 31 (Saudi Arabian) have high fetal hemoglobin (HbF) levels (15 to 30% of total hemoglobin) whereas individuals homozygous for haplotypes 17 (Cameroon), 19 (Benin), and 20 (Bantu) have low HbF levels (1 to 10%). We previously identified several point mutations in the LCR 5'HS-2 that were...

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Identifiers

PMID: 8571932
DOI: 10.1002/(SICI)1096-8652(199601)51:1<12::AID-AJH3>3.0.CO;2-A

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Two mutations in the locus control region hypersensitivity site-2 (5' HS-2) of haplotype 19 beta s chromosomes alter binding of trans-acting factors.PMID 8571932Read ↗

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