Article
Certain mutations observed in the 5' sequences of the G gamma- and A gamma-globin genes of beta S chromosomes are specific for chromosomes with major haplotypes.
Acta haematologica - 1 Jan 1991
Dimovski A J, Oner C, Agarwal S, Gu Y C, Gu L H, Kutlar F, Lanclos K D, Huisman T H
Abstract excerpt
In this paper we describe the distribution of some specific sequence differences in the 5' flanking regions of the A gamma- and G gamma-globin genes from 100 Black adult and 57 newborn SS patients from the southeastern United States, from 76 individuals with AS, S-beta-thal, SC, AC, or A-beta-thal, and from 31 normal individuals. Haplotypes for all adult individuals have been previously determined using various...
Topics
- Adult
- Anemia, Sickle Cell
- Base Sequence
- Black People
- Globins
- Haplotypes
- Hemoglobin C Disease
- Hemoglobin SC Disease
- Humans
- Infant, Newborn
- Molecular Sequence Data