Article
Black beta-thalassemia homozygotes with specific sequence variations in the 5' hypersensitive site-2 of the locus control region have high levels of fetal hemoglobin.
American journal of hematology - 1 Oct 1992
Beris P, Kitundu M N, Baysal E, Oner C, Lanclos K D, Dimovski A J, Kutlar F, Huisman T H
Abstract excerpt
We have sequenced the 5' hypersensitive-2 (5'HS-2) site of the locus control region (LCR) and the promoters of the two gamma-globin genes located on chromosome 11 of a black patient with mild beta-thalassemia (beta-thal) major due to a homozygosity for the C----T mutation at position -88 of the b...
Topics
- Adenine
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Base Sequence
- Black People
- Child
- Chromosomes, Human, Pair 11
- Cytosine
- DNA
- Female
- Fetal Hemoglobin
- Genes
- Genetic Variation
- Globins