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Article

Impact of Genetic Polymorphisms on 6-Thioguanine Nucleotide Levels and Toxicity in Pediatric Patients with IBD Treated with Azathioprine.

Inflammatory bowel diseases - 1 Dec 2015

Lee Mi-Na, Kang Ben, Choi So Yoon, Kim Mi Jin, Woo Sook Young, Kim Jong-Won, Choe Yon Ho, Lee Soo-Youn

Abstract excerpt

BACKGROUND: Thiopurine-related toxicity results in discontinuation of therapy in up to 30% of patients with inflammatory bowel disease. Although thiopurine S-methyltransferase (TPMT) is implicated in toxicity, not all toxicity can be attributed to TPMT polymorphisms. We investigated the effects of polymorphisms of genes involved in thiopurine and folate metabolism pathways on 6-thioguanine nucleotide levels and...

Read the complete abstract on PubMed

Topics

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Share to Anti-Inflammatory Agents, Non-Steroidal
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Guanine Nucleotides

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Share to Leukopenia

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Source

Identifiers

PMID: 26332308
DOI: 10.1097/MIB.0000000000000570

Genes

TPMT
ABCB1
ABCC1
ABCC5
ADK
IMPDH1
IMPDH2
ITPA
TYMS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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