Predictive role of ITPA genetic variants in thiopurine-related myelotoxicity in Crohn's disease patients.

Abstract excerpt

Thiopurines, an effective therapy for Crohn's disease (CD), often lead to adverse events (AEs). Gene polymorphisms affecting thiopurine metabolism may predict AEs. This retrospective study in CD patients (n = 114) with TPMT activity > 5 Units/Red Blood Cells analyzed TPMT (c.238 G > C, c.460 G > A, c.719 A > G), ITPA (c.94 C > A, IVS2 + 21 A > C), and NUDT15 (c.415 C > T) polymorphisms. All patients received...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Azathioprine
• Share to Crohn Disease