Article
Monocyte gene-expression profiles associated with childhood-onset type 1 diabetes and disease risk: a study of identical twins.
Diabetes - 1 Jul 2010
Beyan Huriya, Drexhage Roosmarijn C, van der Heul Nieuwenhuijsen Leonie, de Wit Harm, Padmos Roosmarijn C, Schloot Nanette C, Drexhage Hemmo A, Leslie Richard David
Abstract excerpt
OBJECTIVE: Monocytes in childhood-onset type 1 diabetes show distinct gene expression. We hypothesize that monocyte activation in monozygotic (MZ) twin pairs discordant for childhood-onset type 1 diabetes could reflect distinct stages of the disease process including diabetes susceptibility (differences between twins, both diabetic and nondiabetic, and control subjects) and/or disease progression (differences...
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