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Article

Gene Expression Differences in Skin Fibroblasts in Identical Twins Discordant for Type 1 Diabetes

9 Feb 2012

Abstract excerpt

Clinical studies suggest metabolic memory to hyperglycemia. We tested whether diabetes leads to persistent systematic in vitro gene expression alterations in patients with type 1 diabetes (T1D) compared with their monozygotic, nondiabetic twins. Microarray gene expression was determined in skin fibroblasts (SFs) of five twin pairs cultured in high glucose (HG) for ∼6 weeks. The Exploratory Visual Analysis System...

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PMID: 22315306
DOI: 10.2337/db11-0617

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