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Article

The PI3K signaling pathway as a pharmacological target in Autism related disorders and Schizophrenia

11 Feb 2016

Abstract excerpt

This review is focused in PI3K's involvement in two widespread mental disorders: Autism and Schizophrenia. A large body of evidence points to synaptic dysfunction as a cause of these diseases, either during the initial phases of brain synaptic circuit's development or later modulating synaptic function and plasticity. Autism related disorders and Schizophrenia are complex genetic conditions in which the...

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PMID: 26877878
DOI: 10.1186/s40591-016-0047-9

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