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Parallel genetic and phenotypic evolution of DNA superhelicity in experimental populations of Escherichia coli.

Molecular biology and evolution - 1 Sept 2010

Crozat Estelle, Winkworth Cynthia, Gaffé Joël, Hallin Peter F, Riley Margaret A, Lenski Richard E, Schneider Dominique

Abstract excerpt

DNA supercoiling is the master function that interconnects chromosome structure and global gene transcription. This function has recently been shown to be under strong selection in Escherichia coli. During the evolution of 12 initially identical populations propagated in a defined environment for 20,000 generations, parallel increases in DNA supercoiling were observed in ten populations. The genetic changes...

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PMID: 20392810
DOI: 10.1093/molbev/msq099

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