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Article

Long-term experimental evolution in Escherichia coli. XII. DNA topology as a key target of selection.

Genetics - 1 Feb 2005

Crozat Estelle, Philippe Nadège, Lenski Richard E, Geiselmann Johannes, Schneider Dominique

Abstract excerpt

The genetic bases of adaptation are being investigated in 12 populations of Escherichia coli, founded from a common ancestor and serially propagated for 20,000 generations, during which time they achieved substantial fitness gains. Each day, populations alternated between active growth and nutrient exhaustion. DNA supercoiling in bacteria is influenced by nutritional state, and DNA topology helps coordinate the...

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Identifiers

PMID: 15489515
DOI: 10.1534/genetics.104.035717
PMCID: PMC1449116

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