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Bacterial single-cell genomics enables phylogenetic analysis and reveals population structures from <i>in vitro</i> evolutionary studies

2020-08-25

Abstract excerpt

Single-cell DNA sequencing has the potential to reveal detailed hierarchical structures in evolving populations of cells. Single cell approaches are increasingly used to study clonal evolution in human ageing and cancer, but have not yet been deployed to study evolving microbial populations. Here, we present an approach for single bacterial genomic analysis using FACS isolation of individual bacteria followed by w...

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Literature Corpus work
53d4e4dd-2a49-55e1-a936-03e590dfc114
DOI
10.1101/2020.08.25.266213
Open publication

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Bacterial single-cell genomics enables phylogenetic analysis and reveals population structures from <i>in vitro</i> evolutionary studiesDOI 10.1101/2020.08.25.266213
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