Article
Quantitative cortical synapse proteomics of a transgenic migraine mouse model with mutated Ca(V)2.1 calcium channels.
Proteomics - 1 Jul 2010
Klychnikov Oleg I, Li Ka Wan, Sidorov Igor A, Loos Maarten, Spijker Sabine, Broos Ludo A M, Frants Rune R, Ferrari Michel D, Mayboroda Oleg A, Deelder André M, Smit August B, van den Maagdenberg Arn M J M
Abstract excerpt
Familial hemiplegic migraine type 1 (FHM1) is caused by missense mutations in the CACNA1A gene that encodes the alpha1A pore-forming subunit of Ca(V)2.1 Ca(2+) channels. Knock-in (KI) transgenic mice expressing Ca(V)2.1 Ca(2+) channels with a human pathogenic FHM1 mutation reveal enhanced glutamatergic neurotransmission in the cortex. In this study, we employed an iTRAQ-based LC-LC MS/MS approach to identify...
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