Article
RNA expression profiling in brains of familial hemiplegic migraine type 1 knock-in mice.
Cephalalgia : an international journal of headache - 1 Mar 2014
de Vries Boukje, Eising Else, Broos Ludo A M, Koelewijn Stephany C, Todorov Boyan, Frants Rune R, Boer Judith M, Ferrari Michel D, Hoen Peter A C 't, van den Maagdenberg Arn M J M
Abstract excerpt
BACKGROUND: Various CACNA1A missense mutations cause familial hemiplegic migraine type 1 (FHM1), a rare monogenic subtype of migraine with aura. FHM1 mutation R192Q is associated with pure hemiplegic migraine, whereas the S218L mutation causes hemiplegic migraine, cerebellar ataxia, seizures, and mild head trauma-induced brain edema. Transgenic knock-in (KI) migraine mouse models were generated that carried...
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